Patient & Provider Information

Title Summary Presenter/Author Subject Area Type hf:doc_tags hf:doc_author
State of Maine Adult Substance Use Disorder Provider Toolkit-Jan 2026

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What is Xylazine?

What is Xylazine?
− A non-opioid agent that the FDA originally approved in 1972 as a sedative and analgesic for use in veterinary medicine (not FDA approved for use in humans)
− Acts as a central alpha-2-adrenergic receptor agonist in the brainstem (like clonidine)
o Rapid decrease in the release of norepinephrine and dopamine in the central nervous system (CNS)
o May also bind to other CNS receptors

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Health and Human Services, Adolescent Health

Alcohol Use in Adolescence Adolescents use alcohol more than any other drug, including tobacco and …

Boston Children’s Hospital Adolescent Substance Use & Addiction Program TIP Sheets

Sample Tip Sheet content: Choose one or a small number (< 5) of behaviors to …