Cytochrome P Four Who?: Demystifying Pharmacokinetic Drug Interactions

Do you struggle with knowing if a medication interaction is clinically meaningful? Do you get confused about which medications cause interactions and which are simply along for the ride? This session is devoted to reviewing pharmacokinetic CYP450 enzyme and P-glycoprotein transporter interactions using examples that are medications used for psychiatric and substance use disorders. Learners will leave the session with the ability to describe and evaluate specific medication interactions.

Objectives
• Describe how pharmacokinetic (PK) parameters are used to assess medication interactions
• Describe the CYP450 enzymes including common substrates, inhibitors, and inducers, and the expected timeframe of CYP450 enzyme interactions
• Identify key psych/SUD medications involved in CYP450 enzyme and P-glycoprotein interactions
• Apply PK and medication interaction knowledge to a patient scenario

Audience:
Prescribing clinicians and their teams

Continuing Medical Education
This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of the Maine Medical Education Trust and CCSME. The Maine Medical Education Trust is accredited by the Maine Medical Association Committee on Continuing Medical Education and Accreditation to provide continuing medical education for physicians.

The Maine Medical Education Trust designates this regularly scheduled series for a maximum of 1 AMA PRA Category 1 Credit™. Physicians should only claim credit commensurate with the extent of their participation in the activity.

This activity qualifies for 1 credit of the 3 CME credit requirement for opioid medication education found in P.L. 2015, Chapter 488, Maine’s legislation to address the opioid drug crisis.

*Nurses and Nurse Practitioners will be awarded a certificate of participation with a maximum of 1 AMA PRA Category 1 Credit™.

Contact Hours
1 contact hour for social workers, licensed clinical professional counselors, and behavioral health professionals.
1 contact hour for Alcohol and Drug Counselors pending approval by the Maine Board of Alcohol and Drug Counselors
1 Category I contact hour for psychologists. CCSME is a pre-approved sponsor and provider of Professional Education Activities for Psychologists.
1 contact hour CHES. CCSME is a designated provider of continuing education contact hours (CECH) in health education by the National Commission for Health Education Credentialing, Inc.