Alcohol use disorder (AUD) is a disease that affects one in seven people. 1 And while treatment options exist, more of them, with more efficacy, are needed. Prazosin has been studied for treatment of nightmares in PTSD and for alcohol use disorder (AUD), two conditions with frequent overlap. The results for alcohol use have been mixed. This paper makes a strong case that the presence of low-level alcohol withdrawal predicts the effectiveness of prazosin in AUD.