What is Xylazine? − A non-opioid agent that the FDA originally approved in 1972 as a sedative and analgesic for use in veterinary medicine (not FDA approved for use in humans) − Acts as a central alpha-2-adrenergic receptor agonist in the brainstem (like clonidine) o Rapid decrease in the release of norepinephrine and dopamine in the central nervous system (CNS) o May also bind to other CNS receptors
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